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Nitric oxide (N.O.) is a vital molecule produced by our body, and it plays a crucial role in maintaining good health. It helps in relaxing blood vessels, regulating blood pressure, and improving circulation. Low levels of nitric oxide can lead to various health issues, including high blood pressure, cardiovascular disease, and erectile dysfunction.
If you’re interested in enhancing your athletic performance, you may have heard about nitric oxide supplements. While these supplements don’t actually contain N.O., they do include compounds like l-arginine and l-citrulline that can boost the body’s production of this important molecule.
While the research on the effects of increased N.O. levels on athletic performance s ongoing and not conclusive, there is some evidence to suggest that it may be helpful for high intensity interval training (HIIT) and prolonged aerobic activity.
Some athletes also use N.O. supplements for the “pump” and vascularity they feel during workouts.
Why We Know What We’re Talking About
To help you navigate the world of N.O. supplements, we’ve tested and compiled a list of some of the best nitric oxide supplements on the market, taking into account ingredients, reputable brands, and the latest research.
But why trust us? As certified personal trainers, we have extensive knowledge and experience in the field of fitness and nutrition. We understand the importance of using safe and effective supplements to support our clients’ health and fitness goals. Note that it’s always best to consult your physician before taking any new supplements, as many can interact with current medication or cause adverse effects if you have certain health conditions.
When it comes to ranking the best nitric oxide supplements, we rely on our expertise and research to provide reliable recommendations. We take into consideration factors such as ingredient quality, dosage, and customer feedback to ensure that we are providing accurate and trustworthy information. Our goal is to help you make informed decisions for yourselves and for your clients about their supplement choices, and we take pride in being a reliable source of information in this area.
Here is a quick summary of our findings:
- Best Pre-Workout Nitric Oxide: Transparent Labs Bulk Pre-Workout supplement
- Best Nitric Oxide Supplement For Vascularity: Transparent Labs Citrulline powder
- Best Nitric Oxide Supplement For Bodybuilding: Transparent Labs Nitric Oxide Capsules
- Best Nitric Oxide Supplement For ED: VigRX N.O. Support
Best pre-workout nitric oxide
PRICE
QUALITY
FLAVORS
OVERALL
Pros
- Contains high-quality ingredients and is free from unnecessary fillers or additives
- May help improve energy, focus, and endurance during workouts
- Some users report improved muscle pumps and vascularity
- Comes in several different flavors to suit different preferences
- Offers a transparent label, so users know exactly what they are consuming
Cons
- Some users report experiencing side effects such as jitters, headaches, or upset stomach
- The product is more expensive compared to other pre-workout supplements on the market
- May not work for everyone and some users report not experiencing any significant improvements in their performance or results
- The taste may not be to everyone's liking, and some users report a chalky or gritty texture
- Contains caffeine, which may not be suitable for those who are sensitive to stimulants
Ingredients
Citrulline Malate
Beta-Alanine
BetaPure™ Betaine Anhydrous
Taurine
L-Tyrosine
AlphaSize® Alpha-GPC
PurCaf® Organic Caffeine
L-Theanine
Theobromine
SenActiv®
BioPerine® Black Pepper Fruit Extract
With a scientifically-backed blend of ingredients, fully transparent labeling, and no artificial additives, this powder is the perfect choice for anyone looking to improve their strength, energy, and focus in the gym. Plus, with its proven ability to enhance muscle pumps, stamina, and lean muscle growth, BULK is the ultimate pre-workout supplement for serious athletes and fitness enthusiasts alike.
From my personal experience, the supplement helped me feel more energized and focused during workouts, allowing me to push harder and achieve better results. The supplement also has a good taste and mixes well with water or other liquids. While some customers feel that the supplement is too expensive compared to other pre-workout products on the market, I found the price well worth it.
Best nitric oxide supplement for vascularity
PRICE
QUALITY
FLAVORS
OVERALL
Pros
- Improved athletic performance because of an increase in blood flow and circulation. This can result in improved endurance, better muscle pumps, and reduced soreness after exercise.
- Citrulline has been shown to improve arterial function and blood flow, which can help reduce the risk of heart disease and other cardiovascular conditions.
- Citrulline may help promote muscle growth by increasing the production of nitric oxide, which can improve nutrient delivery to muscles and support protein synthesis.
- Transparent Labs Citrulline powder is made with high-quality ingredients and is generally considered safe and effective when used as directed.
Cons
- Some people may experience digestive issues such as diarrhea, nausea, or stomach cramps when taking citrulline supplements.
- Citrulline may interact with medications used to treat erectile dysfunction, high blood pressure, and other conditions. It is important to consult with a healthcare provider before taking citrulline supplements.
- While citrulline has been shown to be effective for improving athletic performance and supporting heart health in many individuals, it may not work for everyone.
- Citrulline supplements can be expensive, especially when compared to other amino acid supplements.
Ingredients
L-Citrulline
Transparent Labs Citrulline powder is made with high-quality ingredients and is designed to be easily absorbed by the body. It is a popular choice among athletes and fitness enthusiasts looking to enhance their workouts and improve their overall performance.
I recently tried Transparent Labs Citrulline powder, and I have to say I was impressed. Each scoop contains a whopping 2,000 mg of fermented L-citrulline, which can do wonders for increasing blood flow, muscle pumps, and recovery.
What’s great about L-citrulline is that it’s an amino acid that is easy for the body to absorb and convert into L-arginine, one of the building blocks of nitric oxide. This is why it’s become so popular in recent years as a top nitric oxide booster.
One of the things I found interesting about L-citrulline is that it was first isolated from the rind of watermelon, which is where it gets its name. And while the kidneys can store large amounts of citrulline but not arginine, citrulline is considered to be the most important endogenous regulator of nitric oxide production.
Best nitric oxide supplement for bodybuilding
PRICE
QUALITY
FLAVORS
OVERALL
Pros
- Improved athletic performance by increasing blood flow and oxygen delivery to the muscles. This can lead to better muscle endurance, strength, and recovery.
- Enhances muscle pumps
- Made with high-quality, clinically dosed ingredients that are free from artificial colors, sweeteners, or preservatives.
- Easy capsule delivery (no need to drink anything)
Cons
- Potential Side Effects - As with all of these supplements, nitric oxide supplements are generally safe but can cause certain side effects like headaches, dizziness, and nausea. In rare cases, they can also lead to dangerously low blood pressure and increased risk of bleeding.
Ingredients
NO3-T® Arginine Nitrate and Betaine Nitrate
Setria® L-Glutathione
Pine Bark Extract
Vitamin C
AstraGin™
The TL Labs formula contains clinical doses of several hyperemic ingredients, including patented NO3- T® arginine nitrate and betaine nitrate, Setria® reduced L-glutathione, AstraGin™, pine bark proanthocyanidins, and vitamin C.
What I found most impressive was how quickly these ingredients went to work, bolstering my body’s nitric oxide production and facilitating robust blood flow to my skeletal muscle tissue during my workouts. This ultimately led to better performance and faster recovery times.
I particularly appreciated the inclusion of Setria® reduced L-glutathione, which is known for its antioxidant properties and ability to support immune health. And with pine bark proanthocyanidins and vitamin C added to the mix, I felt confident that I was getting a comprehensive blend of ingredients that could support my overall health and fitness.
Best nitric oxide supplement for ED
PRICE
QUALITY
FLAVORS
OVERALL
Pros
- Can improve sexual performance and function
- Can increase libido and improve erectile function.
- Made with high-quality ingredients and is free of artificial colors, flavors, and preservatives.
- Capsules are easy to swallow and do not have a bad taste or aftertaste.
- Quick results (according to many reviewers)
Cons
- Can be expensive compared to other nitric oxide supplements on the market.
- Possible digestive issues such as nausea, stomach cramps, or diarrhea
- Some notice no significant changes in their athletic performance or sexual function.
Ingredients
Velox (L-Citrulline, L-Arginine)
Gelatin
Magnesium Stearate
Silica
VigRX N.O. Support is a formula that contains a powerful, patented extract of L-Citrulline and L-Arginine in the maximum safe dose, providing you with the benefits of both amino acids. By taking VigRX N.O. Support regularly, you can likely improve blood flow to the penis, aiding with a symptom of ED.
The supplement was highly effective at increasing nitric oxide levels, which can lead to improved blood flow and better oxygen delivery to the muscles. I especially appreciated that the supplement is made with high-quality ingredients and is free from unnecessary fillers or additives. I also felt a vast mprovements in overall energy levels and recovery times when using the product.
Nitric Oxide Supplements and ED
Studies have shown that the combination of L-Citrulline and L-Arginine significantly improves blood flow and can enhance erectile function. In fact, research suggests that supplementing with just L-Arginine alone may be nearly useless, while the combination of both ingredients has been found to be highly effective.
Numerous studies have been conducted on the effectiveness of L-Citrulline and L-Arginine for improving blood flow and erectile function. One study published in the Journal of Sexual Medicine found that a combination of L-Citrulline and L-Arginine significantly improved erectile function in men with mild to moderate erectile dysfunction.
Another study, published in the International Journal of Cardiology, found that combining L-Citrulline and L-Arginine improved blood flow and reduced blood pressure in healthy men. This study also found that the effects of the supplement were seen within just eight days.
Nitric oxide supplements for high blood pressure
As fitness professionals, we tend to stay in our lane in terms of supplement recommendations and as such won’t make a recommendation related to medical conditions such as high blood pressure. While we know many people take nitric oxide supplements for high blood pressure, it is generally under the care of their physician.
According to MayoClinic, here’s a summary of what they advise.
L-arginine supplements are sometimes taken by individuals to relax and widen their arteries, potentially helping to reduce blood pressure. However, these supplements are generally unnecessary and may only be beneficial for individuals who have a genuine deficiency.
Research on L-arginine has produced conflicting results. Recent studies suggest that L-arginine may decrease blood pressure, improve cholesterol levels, and improve the overall health of blood vessels. A review of multiple studies revealed that adults with high blood pressure who took daily L-arginine supplements experienced a reduction in their diastolic blood pressure.
L-arginine may work more effectively in promoting heart health when used in conjunction with other vitamins, such as B6 and B12. However, more extensive and well-designed studies are required to confirm these results before experts can endorse regular use of these supplements.
L-arginine drug interactions
It is essential to be aware that L-arginine supplements can interact with certain medications, including blood thinners like aspirin and warfarin, specific diuretics, nitroglycerin, some high blood pressure medications, erectile dysfunction drugs, and diabetes medications.
Individuals who have experienced a heart attack should avoid taking L-arginine, as there are concerns that the supplement may increase the risk of death. Additionally, those with allergies and asthma should exercise caution when using L-arginine supplements.
Individuals who have experienced cold sores or genital herpes should not take L-arginine supplements, as excessive L-arginine levels may activate the virus responsible for these conditions.
Again, if you have high blood pressure and are interested in nitric oxide supplementation, consult with your healthcare provider.
Understanding the Role of Citrulline and Arginine in the Body
Here’s a brief primer on pre-workout supplements and nitric oxide supplementation and why we recommend a product that has high levels of citrulline, a key ingredient in in improving nitric oxide synthesis.
These days, it can be challenging to differentiate between pre-workout powders and nitric oxide supplements, as they all appear to be identical. To verify this, you can simply walk into your local supplement store and browse through the pre-workout section, and you’ll quickly discover that every product has only minor variations in their components.
Many pre-workouts are “concentrated” formulas that deliver a small rush of “pseudo-energy” through the use of harsh stimulants. It’s no wonder that people feel like they “work.” (You might as well drink a pot of coffee before hitting the gym, which is more cost-effective and has similar effects.)
The issue with stimulant-heavy pre-workout formulas is that anything that stimulates the nervous system will constrict blood vessels, increase blood pressure, and counteract nitric oxide production. It’s acceptable to consume caffeine in moderation before working out, but consuming large quantities of stimulants will inevitably reduce the benefits of nitric oxide supplements.
L-Citrulline is a non-essential amino acid that is naturally found in watermelon, among other foods. It is also commonly used as a dietary supplement, particularly for its potential benefits as a nitric oxide supplement.
Nitric oxide is a gas that is naturally produced in the body and is involved in many physiological processes. One of its main roles is to dilate blood vessels, which helps to increase blood flow and oxygen delivery to the body’s tissues. This increased blood flow can improve exercise performance, reduce muscle soreness, and improve overall cardiovascular health.
L-Citrulline is converted in the body into another amino acid called L-arginine, which is a precursor to nitric oxide production. By increasing the availability of L-arginine, L-Citrulline can help to increase nitric oxide production and promote blood vessel dilation.
In addition to its potential benefits for cardiovascular and exercise performance, L-Citrulline may also have other health benefits. It has been studied for its potential role in improving erectile dysfunction and reducing symptoms of mild-to-moderate hypertension.
How to increase nitric oxide naturally
There are many ways to increase nitric oxide naturally, and below, we’ll explore some of the most effective ways.
Eat Nitrate-Rich Foods:
One of the best ways to increase nitric oxide is by consuming nitrate-rich foods, such as leafy greens, beets, and celery. Nitrate is converted to nitric oxide in our body, which helps in relaxing blood vessels and improving blood flow. You can add these foods to your diet by incorporating them into your smoothies or salads.
Exercise Regularly
Regular exercise is not only good for your overall health but also helps in increasing nitric oxide levels in the body. Exercise stimulates the production of nitric oxide synthase, an enzyme responsible for producing nitric oxide in the body. So, make sure to include regular physical activity in your routine, whether it’s through cardiovascular exercises or strength training.
Get Enough Sleep
Getting adequate sleep is essential for maintaining good health, and it can also help in increasing nitric oxide levels. During sleep, our body produces nitric oxide, which helps in regulating blood pressure and improving circulation. So, make sure to get at least 7-8 hours of sleep every night.
Reduce Stress
Stress can have a negative impact on our health and can also lower nitric oxide levels in the body. When we’re stressed, our body releases cortisol, which can damage blood vessels and decrease nitric oxide production. You can reduce stress by practicing relaxation techniques, such as meditation, deep breathing, or yoga.
Increase Vitamin C Intake
Vitamin C is an essential nutrient that helps in increasing nitric oxide levels in the body. It works by protecting nitric oxide from free radical damage, which can decrease its availability in the body. You can increase your vitamin C intake by consuming foods like oranges, strawberries, bell peppers, and kiwi.
Consume Garlic
Garlic is known for its numerous health benefits, and it can also help in increasing nitric oxide levels in the body. It contains a compound called allicin, which helps in relaxing blood vessels and improving blood flow. You can consume garlic raw or cooked, or take a garlic supplement.
Increase Antioxidant Intake
Antioxidants are compounds that protect our body from free radical damage, which can decrease nitric oxide levels in the body. You can increase your antioxidant intake by consuming foods like berries, dark chocolate, and green tea.
Consume L-Arginine
L-arginine is an amino acid that helps in increasing nitric oxide levels in the body. It works by stimulating the production of nitric oxide synthase, the enzyme responsible for producing nitric oxide in the body. You can consume L-arginine through foods like turkey, chicken, pumpkin seeds, and peanuts, or take an L-arginine supplement.
Reduce Alcohol Consumption
Alcohol consumption can have a negative impact on our health and can also lower nitric oxide levels in the body. It can damage blood vessels and decrease nitric oxide production. So, it’s important to limit your alcohol consumption to maintain good health.
Benefits of Nitric Oxide Supplements
According to the study, Dietary nitrate supplementation improves team sport-specific intense intermittent exercise performance, the research indicates that taking N.O. supplements could increase the production of N.O. through the nitrate-nitrite-NO pathway. This, in turn, may improve performance on intermittent recovery, possibly by enhancing the uptake of glucose in muscles or by better preserving muscle excitability. Using N.O. supplements in one’s diet could benefit those who engage in intense intermittent exercise, particularly for players of team sports. It may serve as an effective aid to enhance performance.
Another study on walking, running, and high-intensity cycling showed similar results, with the conclusion that supplementation attributed to increased blood flow levels and improved physiological responses to exercise.
In another study, the results were less conclusive when analyzing performance enhancements from untrained versus highly-trained subjects. The level of training of the participants appears to be a significant factor in the relationship between the use of N.O. supplementation and its ergogenic effects. Research involving healthy individuals who are either untrained or have moderate levels of training demonstrated that N.O. supplements may enhance their capacity for both aerobic and anaerobic exercise. However, in the case of highly trained individuals who were given N.O. supplements, no positive impact on performance was observed.
Frequently Asked Questions
Nitric oxide itself will not make you bigger in terms of muscle size. However, nitric oxide supplements, such as arginine, may increase blood flow and oxygen delivery to the muscles, which can improve performance and potentially lead to increased muscle growth when combined with resistance training.
Nitric oxide supplements, such as arginine, can be taken in several different ways. The most common methods include:
- Capsules or tablets: Nitric oxide supplements are available in capsule or tablet form, which are taken orally with water. Follow the manufacturer’s instructions for dosage and timing.
- Powder: Nitric oxide supplements are also available in powder form, which can be mixed with water or other beverages. Again, follow the manufacturer’s instructions for dosage and timing.
- Pre-workout supplements: Many pre-workout supplements contain nitric oxide as one of their active ingredients. These supplements are usually taken 20-30 minutes before a workout to enhance performance.
- Food sources: Some foods, such as beets and spinach, are naturally high in nitrates, which can be converted to nitric oxide in the body. Adding these foods to your diet can potentially increase nitric oxide levels.
It’s not easy to determine if your nitric oxide levels are low without undergoing specific tests. However, there are some signs and symptoms that may suggest that your nitric oxide levels are suboptimal. These include:
- High blood pressure: Nitric oxide helps to relax and widen blood vessels, which can help to lower blood pressure. If your blood pressure is consistently high, it may be a sign that your nitric oxide levels are low.
- Poor circulation: Nitric oxide plays an important role in promoting blood flow and oxygen delivery to the muscles and other tissues. If you experience cold hands and feet or have trouble with circulation, it may be a sign that your nitric oxide levels are low.
- Fatigue and poor endurance: Nitric oxide is involved in the regulation of energy metabolism and may play a role in reducing fatigue and improving endurance during exercise. If you experience excessive fatigue or have trouble with endurance during physical activity, it may be a sign that your nitric oxide levels are low.
- Erectile dysfunction: Nitric oxide plays a crucial role in promoting blood flow to the penis and maintaining an erection. If you experience difficulties with erectile function, it may be a sign that your nitric oxide levels are low.
If you suspect that you may have low nitric oxide levels, it’s important to speak with a healthcare professional. They can help to assess your nitric oxide status and determine the best course of action.
The timing of nitric oxide supplements may vary depending on the specific supplement and individual factors. Here are some general guidelines:
- Pre-workout: Many people take nitric oxide supplements before a workout to enhance performance. It’s usually recommended to take the supplement 20-30 minutes before exercise to allow time for it to take effect.
- Daily use: Some nitric oxide supplements may be taken daily as part of a general health and wellness regimen. In this case, it’s usually recommended to take the supplement with a meal to enhance absorption.
Before bed: Some research suggests that taking nitric oxide supplements before bed may help to enhance recovery and promote muscle growth. However, more research is needed in this area to determine the optimal timing and dosing.
